Demolition waste represents a significant portion of the total generated waste and has a high importance from both a waste management and a resource efficiency perspective. The urban context is highly relevant to assess the environmental impact of the end-of-life stage of buildings and potential for future reduction to properly design corresponding demolition waste management strategies. The goal of this paper is the development of a framework for the characterization of building material stocks and the assessment of the potential environmental impact associated with the end-of-life of buildings at the urban scale to support decision on waste management strategies. The methodology combines a bottom-up material stock model based on geographical information systems (GIS) and a spatial–temporal database with life cycle assessment (LCA) for the evaluation of end-of-life scenarios. The approach was tested for the city of Esch-sur-Alzette (Luxembourg) and provided significant results on the quantity and the composition of the housing material stock. Two alternative scenarios involving recycling rates of respectively 50% and 70% for inert materials were assessed and an average reduction potential of 25.6% on abiotic depletion potential and 9.2% on global warming potential was estimated.